MONOCLONAL ANTIBODY FOR PREVENTION AND/OR TREATMENT OF ASTROVIRUS DISEASE

摘要

Described herein are methods and compositions related to developing preventative solutions to the problem of astrovirus-related disease and conditions, such as diarrhea. Given the size and complex processing of astrovirus protein, study of this virus is challenging. By instead focusing on molecular subunits critical to viral activity, described herein are methods and compositions allow for recombinant production of astrovirus subunits. Coupled with structure-functional studies, such as a crystallographic mapping of binding with a neutralizing antibody, one is provided the necessary elements necessary to engineering humanized antibodies against different astrovirus serotypes.