CELL LINE, SYSTEM AND METHOD FOR OPTICAL CONTROL OF SECONDARY MESSENGERS

摘要

PROBLEM TO BE SOLVED: To provide a method for generating secondary messengers in a cell.SOLUTION: In a method for generating secondary messengers in a cell, a nucleotide sequence for expressing a chimeric light responsive membrane protein (e.g., rhodopsin) is modified with one or more heterologous receptor subunits {e.g., an adrenergic receptor (alpha1, beta2)}; and the light responsive membrane protein is expressed in a cell for producing a secondary messenger in response to light.SELECTED DRAWING: None