| 发明名称 |
CYCLIC INHIBITORS OF 11 BETA-HYDROXYSTEROID DEHYDROGENASE 1 |
| 摘要 |
<p>This invention relates to novel compounds of the Formula Ik, Im1, Im2, Im5, In1, In2, In5, Io1, Io2, Io5, Ip1, Ip3, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11ß-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.</p> |
| 申请公布号 |
WO2010011314(A1) |
申请公布日期 |
2010.01.28 |
| 申请号 |
WO2009US04261 |
申请日期 |
2009.07.23 |
| 申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH;VITAE PHARMACEUTICALS, INC.;HIMMELSBACH, FRANK;CLAREMON, DAVID, A.;ZHUANG, LINGHANG;LEFTHERIS, KATERINA;XU, ZHENRONG;TICE, COLIN, M. |
发明人 |
HIMMELSBACH, FRANK;CLAREMON, DAVID, A.;ZHUANG, LINGHANG;LEFTHERIS, KATERINA;XU, ZHENRONG;TICE, COLIN, M. |
| 分类号 |
C07D413/10;A61K31/5355;A61P19/10;C07D413/14 |
主分类号 |
C07D413/10 |
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