| 摘要 |
Processes are disclosed for preparing indolinone phenylaminopropanol derivatives, particularly chiral indolinone phenylaminopropanol derivatives of the general formula (I). The processes disclosed may be used to prepare, inter alia, 7-fluoro-1 - [(1 S, 2R)-1-(3-fluorophenyl)-2-hydroxy-3-(methylamino)propyl]-3,3-dimethyl-1,3-dihydro-2H-indol-2-one and 7-fluoro-1 -[(1S, 2/R)-1-(3,5-difluorophenyl)-2-hydroxy-3-(methylamino) propyl]-3,3-dimethyl-1,3-dihydro-2H-indol-2-one. Intermediates of the processes are also disclosed. |
| 申请人 |
WYETH;CHAN, ANITA, WAI-YIN;DING, ZHIXIAN;GHOSH, MOUSUMI;LEVENT, MAHMUT;RAVEENDRANATH, PANOLIL;REN, JIANXIN;ZHOU, MAOTANG;ALIMARDANOV, ASAF;GONTCHAROV, ALEXANDER, V.;NIKITENKO, ANTONIA, A.;POTOSKI, JOHN, R. |
发明人 |
CHAN, ANITA, WAI-YIN;DING, ZHIXIAN;GHOSH, MOUSUMI;LEVENT, MAHMUT;RAVEENDRANATH, PANOLIL;REN, JIANXIN;ZHOU, MAOTANG;ALIMARDANOV, ASAF;GONTCHAROV, ALEXANDER, V.;NIKITENKO, ANTONIA, A.;POTOSKI, JOHN, R. |
