PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS

摘要

PURPOSE: A pharmaceutical composition is provided which is safe and effective in preventing and treating central nervous system disorders. CONSTITUTION: The pharmaceutical composition relates to an aliphatic amine compound substituted with aryl group, an olefin amine compound substituted with aryl group and an acetylene amine compound substituted with aryl group which have a structure of formula I where X is nitrogen or carbon bonded to a substituent species; n is 1, 2, 3, 4, 5, 6 or 7; z' and z'' individually represent hydrogen, C1-C5 alkyl; A, A' and A'' individually represent hydrogen, C1-C7 alkyl or halo; the dashed line in the structure represents a C-C single bond, a C-C double bond or a C-C triple bond; m is 0 or 1 when dashed line represents a C-C single bond or a C-C double bond and m is 0 when dashed line represents a C-C triple bond; p is 0 or 1 when dashed line represents a C-C single bond or a C-C double bond, and p is 0 when dashed line represents a C-C triple bond; the wavy line is a cis(Z) or trans(E) form of the compound when dashed line is C-C double bond; and E and E' individually represents hydrogen, C1-C5 alkyl or halo-substituted C1-C5 alkyl.