发明名称 |
Prevention of Neurodegeneration by Macrolide Antibiotics |
摘要 |
The present disclosure describes the use of macrolide antibiotics to prevent neurodegeneration and to treat or prevent disease and conditions which involve neurodegeneration. While not being limited to a specific mechanism of action, in one embodiment, the macrolide antibiotics inhibit neurodegeneration caused by lysosomal and/or mitochondrial dysfunction. The present disclosure contemplates the use of any macrolide antibiotic and pharmaceutically acceptable derivatives thereof. In a specific embodiment, the macrolide antibiotics include bafilomycin A1, bafilomycin B1 and concanamycin.
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申请公布号 |
US2008221150(A1) |
申请公布日期 |
2008.09.11 |
申请号 |
US20060063715 |
申请日期 |
2006.08.14 |
申请人 |
SHACKA JOHN J;ROTH KEVIN A |
发明人 |
SHACKA JOHN J.;ROTH KEVIN A. |
分类号 |
A61K31/335;A61K31/4375;A61K31/47;A61P25/00 |
主分类号 |
A61K31/335 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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