发明名称 |
Imaging method for the grading of tumors |
摘要 |
The endothelial integrity of microvessels is disturbed in malignant tumors. We invented a method wherein we used MRI to define tumor microvascular permeabilities and correlated these permeabilities with histologic grade in tumors. Using macromolecular MRI contrast medium, we discovered tumor microvascular permeability values were significantly lower in benign tumors than in carcinomas. In addition, we found that the microvascular permeability values demonstrated a strong correlation with the histologic grade of carcinomas as determined by the Scarff-Bloom-Richardson grading system.
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申请公布号 |
US6009342(A) |
申请公布日期 |
1999.12.28 |
申请号 |
US19980032357 |
申请日期 |
1998.02.27 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
BRASCH, ROBERT C.;DALDRUP, HEIKE E.;SHAMES, DAVID M. |
分类号 |
G01R33/563;(IPC1-7):A61B5/055 |
主分类号 |
G01R33/563 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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