发明名称 |
TIME-SEQUENTIAL CYTOMETRY |
摘要 |
An image flow cytometer for observing a microparticulate sample includes a flow chamber having a flow channel that permits the microparticulate sample to travel in a flow direction. An irradiation system scans an irradiation spot across a sensing area of the flow channel in a scan direction different from the flow direction. A detection system detects resultant light from the sensing area and provides a detection signal. An alignment system alters a location of the sensing area with respect to the flow chamber. A control unit causes the irradiation system to scan the irradiation spot during a first measurement interval and operates the alignment system to translate the location of the sensing area along the flow direction. The flow chamber can be mounted to a movable stage in some examples, and the alignment system can move the flow chamber substantially opposite the flow direction using the stage. |
申请公布号 |
US2016370280(A1) |
申请公布日期 |
2016.12.22 |
申请号 |
US201615187346 |
申请日期 |
2016.06.20 |
申请人 |
CAPTL LLC |
发明人 |
Yamamoto Masanobu;Robinson J. Paul |
分类号 |
G01N15/14 |
主分类号 |
G01N15/14 |
代理机构 |
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代理人 |
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主权项 |
1. An image flow cytometer for observing a microparticulate sample, the flow cytometer comprising:
a flow chamber including a flow channel formed therein to permit the microparticulate sample to travel in a flow direction along the flow channel; an irradiation system adapted to scan an irradiation spot across a sensing area of the flow channel in a scan direction different from the flow direction; a detection system that detects a time-varying intensity of resultant light from the sensing area and provides a corresponding detection signal; an alignment system adapted to selectively alter a location of the sensing area with respect to the flow chamber, wherein the alignment system is adapted to selectively change the location of the sensing area at a speed greater than the flow rate; and a control unit communicatively connected to the irradiation system, the detection system, and the alignment system, the control unit adapted to:
cause the irradiation system to scan the irradiation spot during a first measurement interval; andoperate the alignment system to translate the location of the sensing area along the flow direction. |
地址 |
West Lafayette IN US |