发明名称 TIME-SEQUENTIAL CYTOMETRY
摘要 An image flow cytometer for observing a microparticulate sample includes a flow chamber having a flow channel that permits the microparticulate sample to travel in a flow direction. An irradiation system scans an irradiation spot across a sensing area of the flow channel in a scan direction different from the flow direction. A detection system detects resultant light from the sensing area and provides a detection signal. An alignment system alters a location of the sensing area with respect to the flow chamber. A control unit causes the irradiation system to scan the irradiation spot during a first measurement interval and operates the alignment system to translate the location of the sensing area along the flow direction. The flow chamber can be mounted to a movable stage in some examples, and the alignment system can move the flow chamber substantially opposite the flow direction using the stage.
申请公布号 US2016370280(A1) 申请公布日期 2016.12.22
申请号 US201615187346 申请日期 2016.06.20
申请人 CAPTL LLC 发明人 Yamamoto Masanobu;Robinson J. Paul
分类号 G01N15/14 主分类号 G01N15/14
代理机构 代理人
主权项 1. An image flow cytometer for observing a microparticulate sample, the flow cytometer comprising: a flow chamber including a flow channel formed therein to permit the microparticulate sample to travel in a flow direction along the flow channel; an irradiation system adapted to scan an irradiation spot across a sensing area of the flow channel in a scan direction different from the flow direction; a detection system that detects a time-varying intensity of resultant light from the sensing area and provides a corresponding detection signal; an alignment system adapted to selectively alter a location of the sensing area with respect to the flow chamber, wherein the alignment system is adapted to selectively change the location of the sensing area at a speed greater than the flow rate; and a control unit communicatively connected to the irradiation system, the detection system, and the alignment system, the control unit adapted to: cause the irradiation system to scan the irradiation spot during a first measurement interval; andoperate the alignment system to translate the location of the sensing area along the flow direction.
地址 West Lafayette IN US