A 4-OXO-1- (3-SUBSTITUTED PHENYL) -1, 4-DIHYDRO-1, 8-NAPHTHYRIDINE-3-CARBOXAMIDE PHOSPHODIESTERASE-4-INHIBITOR AND A METHOD OF PREPARING SAME

摘要

The current application is directed to a compound of the structural formula (22), crystal form and crystalline free acid thereof, pharmaceutical compositions comprising these compounds and methods of preparing same These compounds are phosphodiesterase-4 inhibitors and are useful in the treatment of asthma and inflammation and are useful for the enhancement of cognition