| 发明名称 |
ANTI-HIV DOMAIN ANTIBODIES AND METHOD OF MAKING AND USING SAME |
| 摘要 |
The invention provides single domain antibodies and derivatives thereof that bind antigens of interest, which are stable, soluble, and do not tend to aggregate. The invention also provides methods for constructing a dAb library and methods for screening dAb libraries to identify the dAb of the invention. The invention also provide methods of treating or preventing conditions by antigen neutralization by administering the dAbs of the invention. |
| 申请公布号 |
US2016207985(A1) |
申请公布日期 |
2016.07.21 |
| 申请号 |
US201514867793 |
申请日期 |
2015.09.28 |
| 申请人 |
The United States of America, as represented by the Secretary, Department of Health & Human Servic |
发明人 |
Dimitrov Dimiter S.;Chen Weizao |
| 分类号 |
C07K16/10;C07K14/73;A61K47/48;A61K39/42;A61K38/17 |
主分类号 |
C07K16/10 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A fusion protein comprising;
a domain antibody comprising SEQ ID NO:36 (m36) or an amino acid molecule having at least 85% sequence identity with m36, and a fusion partner polypeptide. |
| 地址 |
Rockville MD US |
