METHODS AND COMPOSITIONS FOR TREATING POXVIRUSES

摘要

Methods are described for preventing or treating a poxviral infection caused by a poxvirus, preferably a poxvirus of the orthopoxvirus genus, that includes administering to a subject a therapeutically effective amount of a catecholic butane of the following general formula (I) or a pharmaceutical acceptable salt thereof. Specific embodiments of the methods for treating a poxviral infection include administering to the subject a therapeutically effective amount of tetra-O-methyl nordihydroguaiaretic acid. Methods of vaccination to immunize a subject against a poxviral infection are further described that include administering to the subject a vaccine and a catecholic butane or a pharmaceutically acceptable salt thereof at least one of prior to for a therapeutically effective amount of time before, substantially contemporaneously with, and following an incubation period from administration of the vaccine.