发明名称 |
Process for producing trifluoromethyl-substituted 2-alkoxyacetophenone derivatives |
摘要 |
A process for producing a brominated acetal (represented by the formula 3) includes (a) brominating a trifluoromethyl-substituted acetophenone by Br<SUB>2 </SUB>in the presence of an alkylene diol. It is optional to produce a trifluoromethyl-substituted 2-alkoxyacetophenone derivative (represented by the formula 9) by (b) reacting the brominated acetal with a metal alkoxide, thereby converting the brominated acetal into an ether; and (c) hydrolyzing the ether in the presence of an acid catalyst to remove an acetal group from the ether, thereby producing the 2-alkoxyacetophenone derivative. Alternatively, the 2-alkoxyacetophenone can be produced by (a) reacting a trifluoromethyl-substituted phenacyl halide with an acetalization agent, thereby converting the phenacyl halide into an acetal; (b) reacting the acetal with a metal alkoxide, thereby converting the acetal into an ether; and (c) hydrolyzing the ether in the presence of an acid catalyst to remove the acetal group from the ether.
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申请公布号 |
US2006128976(A1) |
申请公布日期 |
2006.06.15 |
申请号 |
US20060347390 |
申请日期 |
2006.02.06 |
申请人 |
CENTRAL GLASS COMPANY, LIMITED |
发明人 |
ISHII AKIHIRO;KANAI MASATOMI;KURIYAMA YOKUSU;YASUMOTO MANABU;INOMIYA KENJIN;OOTSUKA TAKASHI;UEDA KOJI |
分类号 |
C07D317/00;C07C43/315;C07C45/57;C07C45/59;C07C45/60;C07C49/84;C07D309/00;C07D317/16;C07D317/22 |
主分类号 |
C07D317/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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