SYSTEMS AND METHODS FOR OPENING OF A TISSUE BARRIER

摘要

Systems and methods for opening a tissue to a target value using microbubbles are disclosed herein. In an embodiment of a method for opening a tissue to a target value using microbubbles, a region of the tissue is targeted for opening, an acoustic parameter corresponding to the target value is determined, and an ultrasound beam is applied to the target region at the acoustic parameter such that the tissue at the target region is opened to the target value with the microbubbles. The acoustic parameter can be selected to control an acoustic cavitation event and, in some embodiments, controlling an acoustic cavitation event can include controlling a location, number and/or magnitude of acoustic cavitation events.

主权项

1. A method for opening a tissue to a target value using microbubbles, comprising:
targeting a region of the tissue to open; determining at least one acoustic parameter corresponding to the target value, the at least one acoustic parameter is selected to control one or more acoustic cavitation events to open the tissue to the target value to thereby allow passage of molecules and/or agents; and applying an ultrasound beam at the at least one acoustic parameter to the targeted region such that the tissue is opened with the microbubbles to the target value.