| 发明名称 |
MODIFIED AND IMMEDIATE RELEASE FORMULATIONS OF MEMANTINE |
| 摘要 |
The present invention provides immediate release and modified release oral dosage forms. Specifically, the invention provides modified and immediate release pharmaceutical dosage forms containing memantine that exhibit an enhanced release profile and provide reliable absorption. The dosage forms may be used to treat mild, moderate or severe Alzheimer's disease or neuropathic pain. |
| 申请公布号 |
US2016346227(A1) |
申请公布日期 |
2016.12.01 |
| 申请号 |
US201615234870 |
申请日期 |
2016.08.11 |
| 申请人 |
Forest Laboratories Holdings Ltd. |
发明人 |
Dedhiya Mahendria G.;Rastogi Suneel K.;Chhettry Anil;Mani Narasimhan;Rao Niranjan;Periclou Antonia |
| 分类号 |
A61K31/13;A61K9/20;A61K9/48;A61K9/00 |
主分类号 |
A61K31/13 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An oral dosage form comprising memantine or a salt thereof, wherein the dosage form comprises 2.5 to 100 mg of memantine or a salt thereof and provides an in vivo plasma profile comprising:
a mean Tmax of about 8 or more hours; a mean Cmax of less than about 100 ng/ml; and a mean AUC0-∞ of more than about 250 ng h/ml. |
| 地址 |
Hamilton BM |
