REDUCING OR NON-REDUCING POLYNUCLEOTIDE POLYMER FOR DRUG DELIVERY AND METHOD FOR PREPARING SAME

摘要

The present invention relates to a reducing or non-reducing polynucleotide polymer for drug delivery and a method for preparing same, and provides a reducing or non-reducing polymer synthesized by using nucleotides, a method for preparing same, and a polymer composition for drug delivery containing the reducing or non-reducing polymer. The present invention relates to a drug delivery carrier for delivering proteins or peptides to a targeted area through electrostatic attraction, by obtaining a negatively (−) charged polymer by using nucleotides to synthesize the reducing or non-reducing polymer, which is easily breakable due to disulfide bonds, and then bonding the negatively (−) charged polymer with a positively (+) charged protein or peptide, wherein a polymer derived from a non-viral drug delivery carrier containing the novel reducing or non-reducing polymer is capable of effectively enabling escape of a drug, delivered by means of proton buffering activity, from an endosome to other organelles in a cell.

主权项

1. A non-reducing polynucleotide polymer compound represented by a following formula 1: where R is anyone among X is an integer from 0 to 2 and n is an integer from 4 to 2000.