发明名称 |
6,7-TRANS CEPHALOSPORIN-BASED PROBES FOR DETECTING BACTERIA EXPRESSING A METALLO-BETA-LACTAMASE |
摘要 |
The present invention discloses a probe useful for the selective detection of metallo-beta-lactamases, in particular carbapenemases, thereby distinguishing those species of bacteria that are carbapenem-resistant from bacterial strains that are sensitive. Cephalospori based probes that have the 6,7 R,R configuration are susceptible to cleavage by beta-lactamases but cannot distinguish between cleavage by metallo-beta-lactamases and other beta-lactamases. By modifying a side group of the cephalosporin, selectivity can be introduced allowing the probes to distinguish between various types of metallo-beta-lactamases, |
申请公布号 |
US2016333027(A1) |
申请公布日期 |
2016.11.17 |
申请号 |
US201515111576 |
申请日期 |
2015.01.15 |
申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY |
发明人 |
RAO JIANGHONG;SHI HAIBIN |
分类号 |
C07D501/00;C12Q1/66;C12Q1/34 |
主分类号 |
C07D501/00 |
代理机构 |
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代理人 |
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主权项 |
1. A composition comprising a probe selectively cleavable by a metallo-β-lactamase, said probe comprising a cephalosporin having a 6,7-trans configuration and a detectable label attached thereto. |
地址 |
Palo Alto CA US |