HUMANIZED ANTIBODIES AGAINST THE ß-AMYLOYD PEPTIDE
摘要
The invention discloses an isolated antibody that selectively binds to the C-terminal part of Abeta and is humanized or fully human. The antibody of the invention is capable of preventing oligomerisation of Abeta. Furthermore, a method of diagnosis comprising the steps of: (i) Labelling an antibody; (ii) Administering an effective dose of said antibody intranasally or systemically to a subject; and (iii) Detecting the concentration and/or presence of the labelled antibody in body parts of the subject is disclosed.
申请公布号
WO2009033309(A1)
申请公布日期
2009.03.19
申请号
WO2008CH00382
申请日期
2008.09.15
申请人
ESBATECH AG;UNIVERSITY OF ZURICH;EWERT, STEFAN;AUF DER MAUR, ADRIAN;CATTEPOEL, SUSANN;NITSCH, ROGER
发明人
EWERT, STEFAN;AUF DER MAUR, ADRIAN;CATTEPOEL, SUSANN;NITSCH, ROGER