| 摘要 |
The present invention relates to a glucose sensitive vesicle (preferably a multi-lamellar liposome) comprising an insulin-independent glucose transporter integrated into the membrane of the liposome, which further comprises glucokinase, insulin, Mg++ and ATP. Glucose diffuses into the liposome depending on its concentration and will be converted to glucose-6-phosphate. The accumulation of glucose-6-phosphate eventually causes the vesicle to burst. Thus, these liposomes allow an automatic adjustment of insulin levels in a glucose-dependent manner and are, therefore, useful for the treatment of diabetic patients. |
