发明名称 |
MODULATION OF CYTOKINE SIGNALING REGULATORS AND APPLICATIONS FOR IMMUNOTHERAPY |
摘要 |
<p>The present invention relates to regulation of antigen presentation by cytokine signaling regulators in antigen presenting cells, such as dendritic cells. The invention provides methods of modulating antigen presentation through modulation of cytokine signaling regulators, such as SOCS (SOCS1-7, CIS), SHP (SHP-1 and SHP-2) or PIAS (PIAS1, PIAS3, PIASx and PIASy). The present invention provides vaccines and therapies in which antigen presentation is enhanced through modulation of cytokine signaling regulators. The present invention also provides a mechanism to break self tolerance in tumor vaccination methods that rely on presentation of self tumor antigens.</p> |
申请公布号 |
EP1781338(A4) |
申请公布日期 |
2010.02.10 |
申请号 |
EP20050857799 |
申请日期 |
2005.06.23 |
申请人 |
BAYLOR COLLEGE OF MEDICINE |
发明人 |
CHEN, SI-YI;SHEN, LEI;EVEL-KABLER, KEVIN, C.;HUANG, XUE, F. |
分类号 |
C07H21/04;A61K48/00;C12N5/0784;C12N15/113 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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