Preparation of cepham derivatives.

摘要

There is described the production of a 7-epi-3-exomethylenecepham, useful in the synthesis of antibiotic compounds, by a process which comprises reducing a sulfoxide of formula (II): or acetoxymethyl derivative of formula (III), when n is 0 or 1 and R is hydrogen or an acyl group and R<1> is hydrogen, a carboxy-protecting group, or a cation.