NOVEL ETHYL BENZYLPHOSPHINATE DERIVATIVES, PROCESS FOR PRODUCTION THEREOF, AND THEIR USE AS CALCIUM ANTAGONIST

摘要

An ethyl benzylphosphinate derivative represented by the general formula (I) (I) wherein Y represents a hydrogen or fluorine atom, X represents a methylene group or an oxygen atom, and n is 2, 3 or 4. The said compounds can be produced by reacting a compound represented by the following formula (II) (II) wherein Y is as defined above, with a compound represented by the following formula (III) (III) wherein X and n are as defined, and M is an alkali metal atom, in an inert medium. These compounds are useful as a calcium antagonist.