CYCLIC RENIN INHIBITORS CONTAINING 3(S)-AMINO-4-CYCLOHEXYL-2(R)-HYDROXY-BUTANOIC ACID OR 4-CYCLO-HEXYL-(2R, 3S)-DIHYDROXYBUTANOIC ACID OR RELATED ANALOGS

摘要

4/MD3 5/MD4 6/MD5 7/MD6 17785IB TITLE OF THE INVENTION CYCLIC RENIN INHIBITORS CONTAINING 3(S)-AMINO-4-CYCLOHEXYL-2(R)-HYDROXY-BUTANOIC ACID OR 4-CYCLO-HEXYL-(2R, 3S)-DIHYDROXYBUTANOIC ACID OR RELATED ANALOGS Compounds of the formula: (I) 4/MD3 -i- 17785IB are disclosed. These compounds inhibit the angiotensinogen-cleaving action of the natural proteolytic enzyme, renin, and are useful in treating, preventing or managing renin-associated hypertension, hyperaldosteronism, congestive heart failure, and glaucoma.