ENDOTHELIN ANALOGUES WITH ALPHA-AMINE SUBSTITUTION AT RESIDUE 20

摘要

HA575 ENDOTHELIN ANALOGUES WITH ALPHAAMINE SUBSTITUTION AT RESIDUE 20 Endothelin receptor antagonism is exhibited by novel compounds of the formula wherein: ; R9 is alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, or aralkyl; R10 is alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, cycloalkylalkyl, cycloalkenyl, or cycloalkenylalkyl; or R9 and R10 together are an alkylene chain of three to five carbons (e.g., such that A20 is prolyl), optionally substituted with one or two alkyl, alkoxy, aryl, aralkyl, cycloalkyl, or hydroxy groups; and the remaining symbols are as defined in the specification.