| 摘要 |
<p>DNA sequences encoding a porcine Galα(1,3) galactosyl transferase and clones containing such sequences are provided. The porcine Galα(1,3) galactosyl transferase produces the Galα(1,3) Gal epitope on the surfaces or porcine cells. This epitope is recognized by human anti-Galα(1,3) Gal antibodies which are responsible for hyperacute rejection of xenotransplanted pig cells, tissues and organs. Methods of reducing such hyperacute rejection are also provided.</p> |
