A process for the synthesis of (alkyl/alkoxyalkyl/aryl) (trifluoromethylphenyl) methanones and their substituted derivatives as key intermediates for the production of pharmaceutically active compounds

摘要

A new process is described for the preparation of (alkoxyalkyl)(4-trifluoromethylphenyl)methanones. The process comprises reacting a 4-trifluoromethylbenzonitrile with an alkoxyalkyl Grignard in the presence of a suitable polar aprotic solvent. The compound (4-methoxybutyl)(4-trifluoromethylphenyl)methanone is useful as an intermediate in the preparation of the antidepressant drug fluvoxamine.