| 摘要 |
1. A β-lactam antibiotic-containing tablet which comprises 60 to 85% by weight of a β-lactam antibiotic, 1 to 10% by weight of low-substituted hydroxypropylcellulose and/or crosslinked polyvinylpyrrolidone as a disintegrator and 0.5 to 2% by weight of a binder per tablet. 2. A tablet as claimed in claim 1, wherein the binder is polyvinylpyrrolidone, hydroxypropylcellulose or hydroxypropylmethylcellulose. 3. A tablet as claimed in claim 1 or 2 which further comprises 0.5 to 15% by weight of a synthetic sweetener and/or a granulated synthetic sweetener. 4. A tablet as claimed in claim 3, wherein the synthetic sweetener or the granulated synthetic sweetener has a mean particle size of not less than 150 μm. 5. A tablet as claimed in claim 4, wherein the synthetic sweetener or the granulated synthetic sweetener is not less than 150 μm in particle size. 6. A tablet as claimed in claim 3, wherein the granulated synthetic sweetener comprises a synthetic sweetener, and light anhydrous silicic acid and/or hydrated silicon dioxide. 7. A tablet as claimed in any of claims 1 to 6, wherein the β-lactam antibiotic is cefixime or cefdinir. 8. A tablet as claimed in claim 7 which contains 400-mg potency of cefixime, the tablet weight being not greater than 650 mg. 9. A tablet as claimed in claim 1, which contains 300-mg potency of cefdinir, the tablet weight being not greater than 450 mg. 10. A method of producing β-lactam antibiotic-containing tablets which comprises admixing a synthetic sweetener and/or a granulated synthetic sweetener, optionally together with one or more other additives, with a granulation product prepared from the β-lactam antibiotic, disintegrator and binder specified in claim 1, optionally together with one or more excipients, by using ethanol, isopropyl alcohol or an aqueous solution of ethanol or isopropyl alcohol, and then tableting the resulting mixture. |
