发明名称 |
Process for stereospecific hydrolysis of piperidinedione derivatives |
摘要 |
A process for stereospecifically hydrolysing a mixture of the (+) and (-) isomers of a compound of formula (II), in which R is C1-6 alkyl; using a carboxyl esterase enzyme, (I) to form a compound of formula (IIIA), and thereafter separating the resulting compound of formula (IIIA) from the remaining (-) isomer of formula (II); or (ii) to form a compound of formula (IIIB) and thereafter separating the resulting compound of formula (IIIB) from the remaining (+) isomer of formula (II).
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申请公布号 |
US2001018205(A1) |
申请公布日期 |
2001.08.30 |
申请号 |
US20010813755 |
申请日期 |
2001.03.21 |
申请人 |
SMITHKLINE BEECHAM PLC |
发明人 |
CURZONS ALAN DAVID;POWELL LAWSON WILLIAN;KEAY ALAN MARTIN |
分类号 |
C07D211/42;C07D211/40;C07D211/60;C07D211/90;C07D405/12;C12P41/00;C12S99/00;(IPC1-7):C12S13/00 |
主分类号 |
C07D211/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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