发明名称 |
DNAZYME FOR SILENCING THE EXPRESSION OF EGFR |
摘要 |
The invention provides DNAzymes which are capable to silence the expression of EGFR at allele-specific level. These allele-specific DNAzymes against EGFR T790M mutation will knockdown the expression of EGFR T790M mRNA while keeping EGFR wild-type mRNA intact. Hence, these allele-specific DNAzymes against EGFR T790M mutation may overcome T790M-derived TKI resistance accompanied with lower unwanted side effects on normal cells in lung cancer patients. |
申请公布号 |
WO2014110577(A1) |
申请公布日期 |
2014.07.17 |
申请号 |
WO2014US11496 |
申请日期 |
2014.01.14 |
申请人 |
DCB-USA LLC;NATIONAL TAIWAN UNIVERSITY;ACADEMIA SINICA |
发明人 |
YANG, PAN-CHYR;LAI, WEI-YUN |
分类号 |
C12P19/34;A61K48/00;C12N9/00 |
主分类号 |
C12P19/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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