МАКРОЦИКЛИЧЕСКИЕ КОМПЛЕКСЫ МЕТАЛЛОВ И ИХ ПРИМЕНЕНИЕ ДЛЯ ПОЛУЧЕНИЯ КОНЪЮГАТОВ С БИОМОЛЕКУЛАМИ

摘要

The invention relates to macrocyclic metal complexes and their production and use for the production of conjugates with biomolecules. The conjugates are suitable as contrast media in NMR diagnosis and radiodiagnosis as well as for radiotherapy. High relaxivity is achieved by a special liganding of macrocyclic compounds, and a fine-tuning of the relaxivity is made possible.