发明名称 |
New quaternized quinuclidine esters |
摘要 |
Disclosed is a quaternized quinuclidine ester of formula (I): wherein the substituents are defined in the specification and X- represents a pharmaceutically acceptable anion of a mono or polyvalent acid; provided that the group B-(CH2)n-A-(CH2)m- is not a linear C1-4 alkyl group and further provided that the compound is not one of: 1-Allyloxycarbonylmethyl-3-(2-hydroxy-2,2-di-thiophen-2-yl-acetoxy)-1-azonia-bicyclo- [2.2.2]octane; and 1-carboxymethyl-3-(2-hydroxy-2,2-di-thiophen-2-yl-acetoxy)-1-azonia-bicyclo[2.2.2]octane. Also disclosed is a process for producing said esters, pharmaceutical compositions comprising said esters, the use of the ester in the manufacture of a medicament for the treatment of respiratory, urological or gastrointestinal disease or disorder and a combination product comprising said ester.
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申请公布号 |
NZ548583(A) |
申请公布日期 |
2010.05.28 |
申请号 |
NZ20050548583 |
申请日期 |
2005.03.10 |
申请人 |
ALMIRALL PRODESFARMA, SA |
发明人 |
FERNANDEZ FORNER, MARIA DOLORS;PRAT QUINONES, MARIA;BUIL ALBERO, MARIA ANTONIA |
分类号 |
C07D453/02;A61K31/439;A61P11/00;A61P13/00 |
主分类号 |
C07D453/02 |
代理机构 |
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