发明名称 Bromhexine drug intermediates N-methyl-N-o-nitrobenzyl cyclohexylamine synthesis method
摘要 Bromhexine drug intermediates N-methyl-N-o-nitrobenzyl cyclohexylamine synthesis method , comprising the following steps: equipped with a stiffer, a thermometer and a reflux condenser, the reaction vessel was added 600-650ml cyclohexane, 0.69mol N cyclohexyl-methyl-amine (2), slowly added 0.71 -0.73mol o-nitro benzyl amine (3), continued the reaction for 7-8h, 200ml sodium chloride solution was added, cyclohexane was distilled off, the solution temperature is reduced to 10 - 13 0C, sodium sulfite solution was added to adjust the pH of solution to 8-9, extracted with the ethyl acetate solution, dehydrated with dehydrating agent, molecular sieve bleaching, ethyl acetate was distilled off under reduced pressure to get an oily liquid, vacuum distillation, collecting fractions of 105--110 0 C, got N-methyl-N-o-nitrobenzyl cyclohexylamine .
申请公布号 AU2016102254(A4) 申请公布日期 2017.02.16
申请号 AU20160102254 申请日期 2016.12.23
申请人 Xiamen An Pu Dun Information Technology Co., Ltd 发明人 liao, ruer
分类号 C07C209/60;C07C211/35 主分类号 C07C209/60
代理机构 代理人
主权项
地址