| 发明名称 | Genes causing hereditary kidney disease or malformation of the urinary tract | ||
| 摘要 | Isolated nucleotides encoding polypeptides with mutations leading to amino acid substitutions linked to hereditary kidney disease or malformation of the urinary tract are provided herein. Constructs, cells, probes and inhibitory molecules comprising these mutations are also provided and may be used in screening assays for candidate agents to treat or reverse these diseases or alternatively to provide diagnostic tests. Methods of diagnosing subjects likely to develop these diseases or to be carriers of these diseases are also provided. | ||
| 申请公布号 | US9493837(B2) | 申请公布日期 | 2016.11.15 |
| 申请号 | US201314044602 | 申请日期 | 2013.10.02 |
| 申请人 | DUKE UNIVERSITY | 发明人 | Gbadegesin Rasheed A.;Winn Michelle P. |
| 分类号 | C07H21/04;C12Q1/68;C07K14/00 | 主分类号 | C07H21/04 |
| 代理机构 | Andrus Intellectual Property Law, LLP | 代理人 | Andrus Intellectual Property Law, LLP |
| 主权项 | 1. An isolated polynucleotide comprising a cDNA encoding an anillin (ANLN) polypeptide of SEQ ID NO:1 (comprises R431C substitution). | ||
| 地址 | Durham NC US | ||