发明名称 1-SUBSTITUTED-2- 4,-CINNAMYL PIPERAZIN-1,-YL METHYL- BENZIMIDAZOLES THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTIC APPLICATION
摘要 1374406 Derivatives of 2-piperidinomethylbenzimidazole DELALANDE SA 28 June 1973 [6 July 1972] 30849/73 Heading C2C The invention comprises compounds of formula wherein Ar is Ph (optionally substituted by a halogen atom, or by 1-2 Me or 1 or more C 1 -C 4 alkoxy groups), and a process for making them by reacting in an aqueous alcoholicmedium 2. - (4 - cinnamylpiperidinomethyl) benzimidazole with the HCl salt of the 1-(2- aroylethyl)piperidine. Therapeutic compositions for oral administration comprise compounds of the above formula, which have analgesic, vasodilatory, hypotensive, anticholinergic, spasmolytic, atropinic, gastric antisecretory, antiulcerous and diuretic activity.
申请公布号 GB1374406(A) 申请公布日期 1974.11.20
申请号 GB19730030849 申请日期 1973.06.28
申请人 DELALANDE SA 发明人
分类号 C07D403/06;A61K31/495;A61K31/496;A61P1/04;A61P7/10;A61P9/08;A61P9/12;A61P11/08;A61P25/04;A61P25/08;C07D235/14;(IPC1-7):C07D57/00;A61K27/00 主分类号 C07D403/06
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