Process for the Preparation of Dicycloplatin

摘要

The present invention relates to a process to prepare dicycloplatin under mild reactive conditions and at fast reaction rates. The process is reproducible and easy to scale up for industrial application.

主权项

1. A process for preparing dicycloplatin of formula (I),comprising:
combining carboplatin with a corresponding proportion of 1,1-cyclobutane dicarboxylic acid and a solvent to form a suspension; separating formed precipitated solids from the suspension; and drying the solids, wherein the solids comprise the dicycloplatin of formula (I) without a detectable amount of carboplatin present, and wherein the molar ratio of the carboplatin and the 1,1-cyclobutane dicarboxylic acid in the combining step ranges from about 1:1.15 to 1:50.