PROCESS FOR THE MANUFACTURE OF PEPTIDES CONTAINING CYSTINE

摘要

Process for the manufacture of peptides containing cystine Process for the manufacture of peptides which contain more than one disulphide bond characterised in that in one or two aminoacid sequences containing cysteine, in which disulphide bonds are to be produced, two cysteine radicals which are to be linked are protected by a mercapto-protective group R1 of the aralkyl type, two further cysteine radicals are protected by an acylaminomethyl group R2, the protective groups R1 are removed by treatment with iodine in the presence of a polyhalogenated lower aliphatic hydroxy compound or oxo compound, or a corresponding lower alkanoic acid lower alkyl ester, at the same time forming the disulphide bond between these cysteine radicals, which were protected by R1, and at any desired point after removal of the polyhalogenated compound the second disulphide bridge is formed in the usual manner.