RNA-specific binding antibody

摘要

The present invention relates to an antibody being capable of binding specifically to BC200 RNA or its antigen binding fragment, a polynucleotide of encoding the antibody or its antigen binding fragment, a composition, kit and method for detecting BC200 RNA in a sample using the antibody or its antigen binding fragment, and a composition for diagnosis, prevention or treatment of BC200 RNA-associated diseases including the antibody or its antigen binding fragment.

主权项

1. An antibody or its antigen binding fragment, which binds specifically to a region of 50th nucleotide to 120th nucleotide in the nucleotide sequence of a brain cytoplasmic 200 (BC200) RNA having SEQ ID NO: 13
wherein the antibody or its antigen binding fragment comprises: a variable region of heavy chain (VH) comprising an complementarity region (CDR1) consisting of the amino acid sequence of SEQ ID NO: 1, CDR2 consisting of the amino acid sequence of SEQ ID NO: 2, and CDR3 consisting of the amino acid sequence of SEQ ID NO: 3; and, a variable region of light chain (VL) comprising CDR1 consisting of the amino acid sequence of SEQ ID NO: 4, CDR2 consisting of the amino acid sequence of SEQ ID NO: 5, and CDR3 consisting of the amino acid sequence of SEQ ID NO: 6, wherein serine (S) at the fourth position in the amino acid sequence of SEQ ID NO: 6 is substituted with another amino acid.