CHEMICAL ENGINEERING PROCESSES AND APPARATUS FOR THE SYNTHESIS OF COMPOUNDS

摘要

The present invention provides methods for producing cannabinoids and cannabinoid analogs as well as a system for producing these compounds. The inventive method is directed to contacting a compound according to Formula I or Formula II with a cannabinoid synthase.;;Also described is a system for producing cannabinoids and cannabinoid analogs by contacting a THCA synthase with a cannabinoid precursor and modifying at least one property of the reaction mixture to influence the quantity formed of a first cannabinoid relative to the quantity formed of a second cannabinoid.

主权项

1. An in vitro method for producing
(a) tetrahydrocannabinolic acid (THCA) and cannabichromenic acid (CBCA) in different ratios or (b) cannabidiolic acid (CBDA) and cannabichromenic acid (CBCA) in different ratios comprising the steps of: reacting cannabigerolic acid (CBGA) with a cannabinoid synthase in a reaction mixture; modifying one property of the reaction mixture to produce (i) tetrahydrocannabinolic acid (THCA) and cannabichromenic acid (CBCA) when the cannabinoid synthase is tetrahydrocannabinolic acid synthase (THCA synthase);
or (ii) cannabidiolic acid (CBDA) and cannabichromenic acid (CBCA) when the cannabinoid synthase is cannabidiolic acid synthase (CBDA synthase); andrecovering the tetrahydrocannabinolic acid (THCA) and cannabichromenic acid (CBCA) or tetrahydrocannabinolic acid (THCA) and cannabichromenic acid (CBCA) so produced.