Method and reagent for making a radiopharmaceutical composition based on technetium - 99m.

摘要

A method of making a radiopharmaceutical composition by mixing an aqueous solution of pertechnetate with a reducing agent comprising tin metal or stannous ion to reduce the pertechnetate and a complexing agent to form a complex with the reduced technetium, is characterized by incorporating nitrate and or nitrite in an amount to diminish oxidation of Sn<Sup>2-</Sup> to Sn<Sup>4-</Sup>, and hence to prevent re-oxidation of technetium to pertechnetate, during preparation and storage of the complex. Nitrate and nitrite are superior to organic antioxidants previously proposed.

A reagent for the purpose comprises the reducing agent, the complexing agent and tne nitrate and,or nitrite usually in a sterile freeze-dried state.