Nucleic acid encoding chimeric IL-1 receptor type I antagonists

摘要

Featured herein are non-naturally occurring cytokine domains that can be used, inter alia, to modulate cellular signalling responsive to interleukin-1 receptor I (IL-1RI), to treat disorders, and to detect and/or bind to cellular receptors, as well as other agents. Exemplary cytokine domains can contain amino acid residues from at least two parental cytokines domains, for example, receptor binding features, surface features, β strands, and loops from at least two parental cytokines domains.

主权项

1. An isolated nucleic acid comprising a sequence encoding an amino acid sequence at least 95% identical to SEQ ID NO:21.