Activatable antibodies that bind interleukin-6 receptor and methods of use thereof

摘要

The invention relates generally to activatable antibodies that include a masking moiety (MM), a cleavable moiety (CM), and an antibody (AB) that specifically binds to interleukin-6 receptor (IL-6R), and to methods of making and using these anti-IL-6R activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.

主权项

1. An activatable antibody that in an activated state binds Interleukin-6 Receptor (IL-6R) comprising:
an antibody or an antigen binding fragment thereof (AB) that specifically binds to the IL-6R, wherein the antibody comprises a heavy chain comprising an amino acid sequence comprising SEQ ID NO: 1 and a light chain comprising an amino acid sequence comprising SEQ ID NO: 2; a masking moiety (MM) that inhibits the binding of the AB to the IL-6R in an uncleaved state; and a cleavable moiety (CM) that is a polypeptide that functions as a substrate for a protease.