发明名称 Amine intermediates for analgesic compounds
摘要 1,2-Cycloaliphatic diamines and protected diamines of the formulas II and IIa <IMAGE> (II) and <IMAGE> (IIa) wherein the wavy line bonds, p, n, R, R1, R2, Z, m and Q are as defined in the specification, e.g., (+/-)-(5 xi ,6 alpha ,7 beta )-1-[6-methylamino-1-oxaspiro[4.5]dec-7-yl]pyrrolidine, are disclosed and claimed herein. These diamines and protected diamines are useful as intermediates for preparing mono-oxa, and thiaspirocyclic-benzene acetamide and benzamide analgesic compounds.
申请公布号 US4508911(A) 申请公布日期 1985.04.02
申请号 US19840580060 申请日期 1984.02.14
申请人 THE UPJOHN COMPANY 发明人 KAPLAN, LESTER J.
分类号 C07C29/20;C07C33/14;C07C43/315;C07D209/54;C07D307/94;C07D317/72;C07D333/50;C07D493/10;(IPC1-7):C07D307/94 主分类号 C07C29/20
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