发明名称 |
Process for the preparation of 17 alpha -bromoethynyl- and 17 alpha -iodoethynyl-17 beta -hydroxy steroids and novel products thereof |
摘要 |
A process for preparing bromine- or iodine-unlabeled or radioactively labeled 17 alpha -bromoethynyl- and 17 alpha -iodoethynyl-17 beta -hydroxy steroids of the androstane and estrane series of the partial formula <IMAGE> wherein is a single bond or a double bond, V is a carbon-carbon bond or a methylene group, R is hydrogen or methyl, and X is bromine or iodine, from corresponding 17 alpha -ethynyl-17 beta -hydroxy steroids, comprises treating the starting steroid in an inert solvent with a brominating agent or an iodinating agent in the presence of a silver salt. The process enables production of old and new compounds having value as pharmacologically active compounds and also as diagnostic agents when the iodine or bromine is radioactive.
|
申请公布号 |
US4550100(A) |
申请公布日期 |
1985.10.29 |
申请号 |
US19830552537 |
申请日期 |
1983.11.16 |
申请人 |
SCHERING AKTIENGESELLSCHAFT |
发明人 |
HOFMEISTER, HELMUT;SCHULZE, PAUL E.;ANNEN, KLAUS;LAURENT, HENRY;WIECHERT, RUDOLF |
分类号 |
G01N33/53;A61K51/00;A61K51/04;C07J1/00;C07J63/00;(IPC1-7):C07J1/00;A61K31/56 |
主分类号 |
G01N33/53 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|