| 发明名称 |
Immunosuppressant compound. |
| 摘要 |
<p>Described is a process for producing a new immunosuppressant, "demethomycin" (L-682,993) a C-31 demethylated analog of L-679,934 under novel fermentation conditions utilizing the microorganism, Actinoplanacete sp., (Merck Culture Collection MA 6559) ATCC No. 53771. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.</p> |
| 申请公布号 |
EP0349049(A2) |
申请公布日期 |
1990.01.03 |
| 申请号 |
EP19890201609 |
申请日期 |
1989.06.20 |
| 申请人 |
MERCK & CO. INC. |
发明人 |
INAMINE, EDWARD S.;ARISON, BYRON H.;CHEN, SHIEH-SHUNG T.;WICKER, LINDA S. |
| 分类号 |
A61K31/395;A61K35/74;A61P37/06;C07D213/50;C07D213/79;C07D493/18;C07D498/18;C07G99/00;C07H19/01;C12P17/18;C12R1/01 |
主分类号 |
A61K31/395 |
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