发明名称 |
DIAGNOSTIC METHODS FOR DETECTING LYMPHOMAS IN HUMANS |
摘要 |
<p>The sequence of the protein coding regions of the bcl-2 gene are provided as well as bacterial clones which produce the proteins. Assays are provided for detecting a class of B-cell neoplasms associated with a chromosome translocation between chromosomes 14 and 18. This translocation is involved in the majority of cases of human follicular lymphomas. One assay employs an antibody which is immunoreactive with a human protein which is over-expressed due to the chromosome translocation. Another assay involves measurement of the amount of mRNA which hybridizes to the gene proximal to the translocation break-point.</p> |
申请公布号 |
EP0252685(B1) |
申请公布日期 |
1993.06.16 |
申请号 |
EP19870305863 |
申请日期 |
1987.07.02 |
申请人 |
THE WISTAR INSTITUTE |
发明人 |
TSUJIMOTO,YOSHIHIDE;CROCE,CARLOS M |
分类号 |
C12N15/09;C07K14/00;C07K14/005;C07K14/195;C07K14/435;C07K14/82;C07K16/00;C12N15/12;C12P21/00;C12P21/02;C12P21/08;C12Q1/68;C12R1/01;G01N33/574;G01N33/577 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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