| 摘要 |
The invention concerns novel aryl glycinamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof, the symbols having the following meanings: R<1> and R<2> together with the nitrogen atom to which they are bound form a ring of formula (II) shown in which p is 2 or 3 and X stands for oxygen, N(CH2)nR<6> or CR<7>R<8>; and R<3>, R<4>, R<5>, R<6>, R<7>, R<8>, Ar and n have the meanings indicated in the description. The invention also concerns the production and use of these substances. The novel compounds are valuable neurokinin (tachykinin) antagonists.
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| 申请人 |
BOEHRINGER INGELHEIM KG, 55218 INGELHEIM, DE |
发明人 |
SCHNORRENBERG, GERD, DIPL.-CHEM. DR., 55435 GAU-ALGESHEIM, DE;DOLLINGER, HORST, DIPL.-CHEM. DR., 55218 INGELHEIM, DE;ESSER, FRANZ, DIPL.-CHEM. DR., 55218 INGELHEIM, DE;BRIEM, HANS, DR., 55257 BUDENHEIM, DE;JUNG, BIRGIT, DR., 55411 BINGEN, DE;SPECK, GEORG, DIPL.-CHEM. DR., 55218 INGELHEIM, DE |
