PIPERIDINE AND PIPERAZINE DERIVATIVES AS INHIBITORS OF THE ABETA FIBRIL FORMATION

摘要

A compound of formula (I) wherein X is (II) or (III) wherein R' is a group (a), R is a group (e) or (f) wherein n is 0 to 3. In particular the agents of the invention inhibit the formation of β-amyloid (Aβ) peptide into neurotoxic fibrils, thereby acting to prevent or slow down the accumulation of amyloid protein deposits in the brain.