发明名称 |
Crystalline diacylhydrazine and the use thereof |
摘要 |
Crystalline diacylhydrazine and the use thereof The present disclosure provides crystalline polymorphic and amorphous forms of (R) 3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N'-(2-ethyl-3-methoxy-benzoyl)-hydrazide (Compound 1) or (S)-3,5-dimethyl-benzoic acid N-(1 -tert-butyl-butyl)-N'-(2-ethyl-3-methoxy benzoyl)-hydrazide (Compound 2). The present disclosure further provides compositions comprising crystalline polymorphic and amorphous forms of Compound 1 or Compound 2 and an excipient, methods of making crystalline polymorphic or amorphous forms of Compound 1 or Compound 2, and methods of using crystalline polymorphic or amorphous forms of Compound 1 or Compound 2 to regulate gene expression in a cell or in a subject. |
申请公布号 |
AU2015203085(B2) |
申请公布日期 |
2016.11.10 |
申请号 |
AU20150203085 |
申请日期 |
2015.06.10 |
申请人 |
Intrexon Corporation |
发明人 |
Hormann, Robert E.;Shulman, Inna;Rodel, Eva;Hilfiker, Rolf;Depaul, Susan M. |
分类号 |
C07C243/18;C12N5/10 |
主分类号 |
C07C243/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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