PROCESS FOR PREPARING NEW D-HOMO-STEROIDS

摘要

D-Homosteroids of the formula in which R<3> is (H,H) or ( alpha -H, beta -O-acyl), R<13> is lower alkyl, R<17a beta > is H or acyl, R<17a alpha > is ethynyl, 1-propynyl, vinyl, chloroethynyl, butadienyl or propadienyl, and the dotted line in the A ring indicates an additional C-C bond in the 4,5 or 5(10) position. These D-homosteroids have hormonal activity and can be prepared in a manner known per se starting from the 17-keto-D-homosteroids corresponding to the D-homosteroids of the formula I, on the one hand by reaction of these 17-ketosteroids with an organometallic compound supplying a radical R<17a alpha > or, on the other hand, by following this reaction by acylation of the resulting 17a beta -hydroxy-D-homosteroid.