SUBSTITUTED CYCLIC AMINES

摘要

The invention relates to new cyclic amines of the formulae: …… wherein;… Z and Y are each alkylene containing one to about five carbon atoms in the principal chain or said alkylene substituted with OH, alkanoyloxy, alkoxy, mercapto or alkylmercapto;… each of R1, R2 and R3 is independently H, alkyl, aryl, halo, alkoxy, alkenyloxy, alkylsulfinyl, alkylsulfonyl, alkylmercapto, cyano, carboxy, carbalkoxy, carboxamido, sulfamoyl, trifluoromethyl, hydroxy, hydroxyalkyl, acyloxy, alkylamino, sulfonylamino, or acylamino; and R1 and R2, when taken together, form a methylenedioxy or -O-CO-O-;… Ar is heteroaryl, cycloalkyl or …… wherein,… R1, R2 and R3 are as hereindescribed; and… R is H, alkyl, cycloalkyl, aryl, aralkyl, alkenyl, alkynyl, carboalkoxy, or CONR4R5 wherein each of R4 and R5 is H or alkyl; wherein the total number of carbon atoms in each hydrocarbyl group is up to 10;… and acid addition salts thereof. …These compounds possess useful pharmaceutical activities, especially selective cardiotonic activity, antihypertensive activity and anti-allergic activity. …Furthermore, the invention relates to a process for preparing said compounds.