Acetonitrile solvate of an alpha -aminoacyl chloride hydrochloride

摘要

A method for chlorinating the carboxylic group of alpha -aminoacids (e.g. hydroxyphenyl-glycine) is described wherein the aminoacid is suspended in an optionally solvate-forming solvent, treated with an excess of gaseous HCl and then with a chlorinating agent having the general formula [SOaCl2.R1R2NCHO] (e.g. SO Cl2.(CH3)2NCHO). A typical compound thus obtained is the dioxane hemisolvate of D(-)2-(p-hydroxyphenyl)glycyl chloride hydrochloride.